< public service announcement >
If you run linux, the SMP client works great there, huge point-per-day advantage over all the other platforms.
The Win SMP client I'm running now, it supports quad core, but it's also beta, and very tempermental. Note the 1700+ point WU's I'm starting to crank out though, heh. One more in the oven about done.
It doesn't install itself nicely as a service, they want you to watch it for bugs, but it can be done manually.
Their linux, mac, and windows SMP clients prefer quad core but run okay on dual-core as well (it still spawns 4 threads, but a future version of GROMACs, their science core, will support n threads; future-proofing). They've got tight time deadlines though, so have let it to run 12-18 hours minimum a day to hit the deadline. They'll slacken it a lot once it's no longer in beta.
BOINC will run 4 WU simultaneously, but so far only F@H has a native SMP app. The difference, of course, is purely philosophical from the user perspective.
</ public service announcement >
I guess I'd recommend BOINC for ya, though. If for whatever reason you don't like running it as a service, you'll absolutely hate the beta SMP client. I love the console client, and I dont even really like the SMP client.  I just like the work units..
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(unless you do console, which I don't want)
